Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup.

ABSTRACT: Depressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depression, but it is currently unclear whether depressive symptoms in individuals without a clinical diagnosis have reliable neural underpinnings. We investigated to what extent the severity of depressive symptoms in a non-clinical sample was associated with imbalances in the complex dynamics of the brain during rest. To this end, a novel intrinsic ignition approach was applied to resting-state neuroimaging data from sixty-nine participants with varying degrees of depressive symptoms following a rel

SUBMITTER: Alonso Martinez S 

PROVIDER: S-EPMC7284067 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature