In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective.

ABSTRACT: When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory epithelium is the first tissue that inhaled substances directly interact with. Acute inhalation toxicity testing for regulatory purposes is currently performed only in rats and/or mice according to OECD TG403, TG436, and TG433 test guidelines. Such tests are biased by the differences in the respiratory tract architecture and function across species, making it difficult to draw conclusions on the potential hazard of inhaled compounds in humans. Research efforts have been therefore focused on developing alternative, human-relevant models, with emphasis on the creation of

SUBMITTER: Movia D 

PROVIDER: S-EPMC7284111 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature