Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni.

ABSTRACT: Neglected tropical diseases are of growing worldwide concern and schistosomiasis, caused by parasitic flatworms, continues to be a major threat with more than 200 million people requiring preventive treatment. As praziquantel (PZQ) remains the treatment of choice, an urgent need for alternative treatments motivates research to identify new lead compounds that would complement PZQ by filling the therapeutic gaps associated with this treatment. Because impairing parasite neurotransmission remains a core strategy for control of parasitic helminths, we screened a library of 708 compounds with validated biological activity in humans on the blood fluke Schistosoma mansoni, measuring their effect on the motility on schistosomulae and adult worms. The primary phenotypic screen performed on schisto

SUBMITTER: Duguet TB 

PROVIDER: S-EPMC7284125 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature