Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes.

ABSTRACT:

Background

Caloric restriction (CR) delays the onset of metabolic and age-related disorders. Recent studies have demonstrated that formation of beige adipocytes induced by CR is strongly associated with extracellular remodeling in adipose tissue, decrease in adipose tissue inflammation, and improved systemic metabolic homeostasis. However, beige adipocytes rapidly transition to white upon CR withdrawal through unclear mechanisms.

Materials and methods

Six-week old C57BL6 mice were fed with 40% CR chow diet for 6 weeks. Subsequently, one group of mice was switched back to ad libitum chow diet, which was continued for additional 2 weeks. Adipose tissues were assessed histologically and biochemically for beige adipocytes.

Results

Beige adipocytes induced by CR rapidly tr

SUBMITTER: Mooli RGR 

PROVIDER: S-EPMC7284285 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature