Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults.

ABSTRACT:

Importance

Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD), yet much of COPD risk remains unexplained.

Objective

To determine whether dysanapsis, a mismatch of airway tree caliber to lung size, assessed by computed tomography (CT), is associated with incident COPD among older adults and lung function decline in COPD.

Design, setting, and participants

A retrospective cohort study of 2 community-based samples: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study, which involved 2531 participants (6 US sites, 2010-2018) and the Canadian Cohort of Obstructive Lung Disease (CanCOLD), which involved 1272 participants (9 Canadian sites, 2010-2018), and a case-control study of COPD: the Subpopulations and Intermediate Outcome Measures in

SUBMITTER: Smith BM 

PROVIDER: S-EPMC7284296 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature