The temporal dynamics of humoral immunity to Rickettsia typhi infection in murine typhus patients.

ABSTRACT:

Objectives

This study examined individuals with Rickettsia typhi infection in the Lao People's Democratic Republic (Lao PDR) to (a) investigate humoral immune dynamics; (b) determine the differences in reference diagnostic results and recommend appropriate cut-offs; (c) determine differences in immune response after different antibiotic treatments; and (d) determine appropriate diagnostic cut-off parameters for indirect immunofluorescence assay (IFA).

Methods

Sequential serum samples from 90 non-pregnant, adults were collected at seven time-points (days 0, 7, 14, 28, 90, 180 and 365) as part of a clinical antibiotic treatment trial. Samples were tested using IFA to determine IgM and IgG antibody reciprocal end-point titres against R. typhi and PCR.

Results

For all 90

SUBMITTER: Phakhounthong K 

PROVIDER: S-EPMC7284305 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature