Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material.

ABSTRACT: Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation of novel carriers to transport DNA is an important research line in the medical field. Hybrid compounds such as metallo-liposomes, containing a mixture of lipids, were prepared and characterized. Cationic metal lipids derived from the [Ru(bpy)₃]²⁺ complex, RuC11C11 or RuC19C19, both with different hydrophobic/lipophilic ratios, were mixed with the phospholipid DOPE. A relation between the size and the molar fraction α was found and a multidisciplinary study about the interaction between the metallo-liposomes and DNA was performed. The metallo-liposomes/DNA association was quantified and a relationship between K_app and α was obtained.

SUBMITTER: Lebron JA 

PROVIDER: S-EPMC7284339 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature