Optimization of Curcumin Nanocrystals as Promising Strategy for Nose-to-Brain Delivery Application.

ABSTRACT: Intranasal (IN) drug delivery is recognized to be an innovative strategy to deliver drugs to the Central Nervous System. One of the main limitations of IN dosing is the low volume of drug that can be administered. Accordingly, two requirements are necessary: the drug should be active at a low dosage, and the drug solubility in water must be high enough to accommodate the required dose. Drug nanocrystals may overcome these limitations; thus, curcumin was selected as a model drug to prepare nanocrystals for potential IN administration. With this aim, we designed curcumin nanocrystals (NCs) by using Box Behnken design. A total of 51 formulations were prepared by the sonoprecipitation method. Once we assessed the influence of the independent variables on nanocrystals' mean diameter, the formul

SUBMITTER: Bonaccorso A 

PROVIDER: S-EPMC7284456 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature