Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?

ABSTRACT: Epigenetic alterations, as a cancer hallmark, are associated with cancer initiation, progression and aggressiveness. Considering, however, that these alterations are reversible, drugs that target epigenetic machinery may have an inhibitory effect upon cancer treatment. The traditional drug discovery pathway is time-consuming and expensive, and thus, new and more effective strategies are required. Drug Repurposing (DR) comprises the discovery of a new medical indication for a drug that is approved for another indication, which has been recalled, that was not accepted or failed to prove efficacy. DR presents several advantages, mainly reduced resources, absence of the initial target discovery process and the reduced time necessary for the drug to be commercially available. There are numerous

SUBMITTER: Moreira-Silva F 

PROVIDER: S-EPMC7284583 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature