Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action.

ABSTRACT: Overconsumption of high-fat and cholesterol-containing diets is detrimental for metabolism and mitochondrial function, causes inflammatory responses and impairs insulin action in peripheral tissues. Dietary fatty acids can enter the brain to mediate the nutritional status, but also to influence neuronal homeostasis. Yet, it is unclear whether cholesterol-containing high-fat diets (HFDs) with different combinations of fatty acids exert metabolic stress and impact mitochondrial function in the brain. To investigate whether cholesterol in combination with different fatty acids impacts neuronal metabolism and mitochondrial function, C57BL/6J mice received different cholesterol-containing diets with either high concentrations of long-chain saturated fatty acids or soybean oil-derived poly-unsat

SUBMITTER: Schell M 

PROVIDER: S-EPMC7284591 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature