The Grafting of Multifunctional Antithrombogenic Chemical Networks on Polyurethane Intravascular Catheters.

ABSTRACT: Intravascular catheters (IVCs) and other medical tubing are commonly made of polymeric materials such as polyurethane (PU). Polymers tend to be fouled by surface absorption of proteins and platelets, often resulting in the development of bacterial infections and thrombosis during catheterization, which can lead to embolism and death. Existing solutions to fouling are based on coating the IVCs with hydrophilic, anti-thrombogenic, or antimicrobial materials. However, the delamination of the coatings themselves is associated with significant morbidity, as reported by the United States Food and Drug Administration (FDA). We developed a lubricious, antimicrobial, and antithrombogenic coating complex, which can be covalently attached to the surface of industrial PU catheters. The coating complex

SUBMITTER: Roth Y 

PROVIDER: S-EPMC7284597 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature