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Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.


ABSTRACT:

SUBMITTER: Sivapalan P 

PROVIDER: S-EPMC7284668 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.

Sivapalan Pradeesh P   Ulrik Charlotte Suppli CS   Bojesen Rasmus Dahlin RD   Lapperre Therese Sophie TS   Eklöf Josefin Viktoria JV   Håkansson Kjell Erik Julius KEJ   Browatzki Andrea A   Tidemansen Casper C   Wilcke Jon Torgny JT   Janner Julie J   Gottlieb Vibeke V   Meteran Howraman H   Porsbjerg Celeste C   Madsen Birgitte Lindegaard BL   Moberg Mia M   Pedersen Lars L   Benfield Thomas Lars TL   Lundgren Jens Dilling JD   Knop Filip Krag FK   Biering-Sørensen Tor T   Ghanizada Muzhda M   Sonne Tine Peick TP   Bødtger Uffe Christian Steinholtz UCS   Jensen Sidse Graff SG   Rasmussen Daniel Bech DB   Brøndum Eva E   Tupper Oliver Djurhuus OD   Sørensen Susanne Wiemann SW   Alstrup Gitte G   Laursen Christian Borbjerg CB   Møller Ulla Weinrich UW   Sverrild Asger A   Jensen Jens-Ulrik Stæhr JS  

Trials 20200610 1


<h4>Objectives</h4>The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as "days alive and out of hospital" as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death.<  ...[more]

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