Known Antimicrobials Versus Nortriptyline in Candida albicans: Repositioning an Old Drug for New Targets.

ABSTRACT: Candida albicans has the capacity to develop resistance to commonly used antimicrobials, and to solve this problem, drug repositioning and new drug combinations are being studied. Nortriptyline, a tricyclic antidepressant, was shown to have the capacity to inhibit biofilm and hyphae formation, along with the ability to efficiently kill cells in a mature biofilm. To use nortriptyline as a new antimicrobial, or in combination with known drugs to increase their actions, it is important to characterize in more detail the effects of this drug on the target species. In this study, the Candida albicans GRACE ™ collection and a Haplo insufficiency profiling were employed to identify the potential targets of nortriptyline, and to classify, in a parallel screening with amphotericin B, caspofungin, a

SUBMITTER: Caldara M 

PROVIDER: S-EPMC7284794 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature