The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles.

ABSTRACT: Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box-Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studies were undertaken to support the results from dissolution tests and to evaluate the impact of the crosslinking ratio on the microparticles' characteristics. The zidovudine dissolution behavior had a complex nature which comprised two phases: an initial burst effect followed with a prolonged release stage. The initial drug release, which can be modulated by the crosslinking degree, was primarily governed by the dissolution of the drug crystals located on the microparticles' surfaces. In turn, th

SUBMITTER: Szymanska E 

PROVIDER: S-EPMC7284795 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature