In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human.
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ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC7284918 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human.
Cui Yunhai Y Claus Stephanie S Schnell David D Runge Frank F MacLean Caroline C
Pharmaceutics 20200428 5
The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass metabolism. The purpose of this study is to evaluate a new human intestine model, EpiIntestinal microtissues, as a tool for the prediction of oral absorption and metabolism of drugs in human intestine. The activities of relevant drug transporters and dr ...[more]
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