Anxiolytic Activity and Brain Modulation Pattern of the α-Casozepine-Derived Pentapeptide YLGYL in Mice.

ABSTRACT: α-Casozepine (α-CZP) is an anxiolytic-like bioactive decapeptide derived from bovine αs1‑casein. The N-terminal peptide YLGYL was previously identified after proteolysis of the original peptide in an in vitro digestion model. Its putative anxiolytic-like properties were evaluated in a Swiss mice model using a light/dark box (LDB) after an intraperitoneal injection (0.5 mg/kg). The effect of YLGYL on c-Fos expression in brain regions linked to anxiety regulation was afterwards evaluated via immunofluorescence and compared to those of α-CZP and diazepam, a reference anxiolytic benzodiazepine. YLGYL elicited some anxiolytic-like properties in the LDB, similar to α‑CZP and diazepam. The two peptides displayed some strong differences compared with diazepam in terms of c-Fos expression modulatio

SUBMITTER: Benoit S 

PROVIDER: S-EPMC7285003 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature