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Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I₂-Imidazoline Receptor Ligand MCR5.

ABSTRACT: Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety- and depressive-like behaviour, are present in Alzheimer's disease (AD), together with memory decline. I₂-imidazoline receptors (I₂-IRs) have been associated with neuropsychiatric and neurodegenerative disorders, further, I₂-IR ligands have demonstrated a neuroprotective role in the central nervous system (CNS). In this study, we assessed the effect of the I₂-IR ligand MCR5 on both cognitive and non-cognitive symptoms in the Senescence accelerated mice prone 8 (SAMP8) mouse model. Oral administration of I₂-IR ligand MCR5 (5 mg/kg/day for four weeks) in 10-month SAMP8 mice ameliorated both BPSD-like phenotype and cognitive decline by attenuating depressive

SUBMITTER: Vasilopoulou F

PROVIDER: S-EPMC7285228 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Dataset Information

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I₂-Imidazoline Receptor Ligand MCR5.

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Dataset Information

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I₂-Imidazoline Receptor Ligand MCR5.