Delayed Addition of Template Molecules Enhances the Binding Properties of Diclofenac-Imprinted Polymers.

ABSTRACT: It has been reported that in the molecular imprinting technique, the use of preformed oligomers instead of functional monomers increases the stability of the non-covalent interactions with the template molecule, providing a sharp gain in terms of binding properties for the resulting imprinted polymer. Based on this theory, we assumed that the delayed addition of template molecules to a polymerization mixture enhances the binding properties of the resulting polymer. To verify this hypothesis, we imprinted several mixtures of 4-vinylpyridine/ethylene dimethacrylate (1:6 mol/mol) in acetonitrile by adding diclofenac progressively later from the beginning of the polymerization process. After polymerization, the binding isotherms of imprinted and non-imprinted materials were measured in acetoni

SUBMITTER: Anfossi L 

PROVIDER: S-EPMC7285371 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature