Incidence of second malignancies in individuals diagnosed with malignant peripheral nerve sheath tumors.

ABSTRACT:

Background

The incidence of malignant peripheral nerve sheath tumors (MPNSTs) is low in the general population, although individuals with Neurofibromatosis Type I (NF1) are particularly susceptible. These tumors generally have a high probability of metastasis. The rate and types of second malignancies (SMNs) after a primary diagnosis of MPNST are not well characterized. We aimed to quantify the rate of SMNs among individuals with a first primary MPNST using population-based data.

Methods

We estimated age-standardized incidence rates (SIRs) for SMNs among 1,579 primary MPNST cases between ages 0-85+ using SEER 18 (2000-2015). We estimated incidence rate ratios (IRRs) and 95% confidence intervals (95% CI) for SMNs in MPNST cases compared with general population rates. We condu

SUBMITTER: Williams LA 

PROVIDER: S-EPMC7285390 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature