Substance P enhances the local activation of NK₁R-expressing c-kit⁺ cardiac progenitor cells in right atrium of ischemia/reperfusion-injured heart.

ABSTRACT:

Background

Localization of neurokinin 1 receptor (NK₁R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK₁R signal pathways in the RA remains unclear. Sprague-Dawley rats were randomly divided into 4 groups (n = 22 each); subjected to sham, ischemia/reperfusion-injury (I/R), I/R with 5 nmole/kg SP injection (SP + I/R), and SP + I/R with 1 mg/kg RP67580 injection (RP, a selective non-peptide tachykinin NK₁R antagonist) (RP/SP + I/R). The left anterior descending coronary artery was occluded for 40 min followed by 1 day reperfusion with SP or SP + RP or without either. After 1 day, both atria and ventricles as well as the heart apexes wer

SUBMITTER: Jeong YM 

PROVIDER: S-EPMC7285458 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature