Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

ABSTRACT:

Background

Parkinson's disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson's Study (n = 147 typical PD cases, n = 162 controls).

Results

All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed by self-reporting questionnaires. Stool samples from these individuals were first analysed by 16S rRNA gene sequencing. Second, we predicted the potential secretion for 129 microbial metabolites through personalised metabolic modelling u

SUBMITTER: Baldini F 

PROVIDER: S-EPMC7285525 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature