Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review.

ABSTRACT:

Background

Thyroid hormone has been shown to be involved in carcinogenesis via its effects on cell proliferation pathways. The objective of this study is to determine the association between subclinical hypothyroidism (SCH) and the risk of incident cancer and cancer mortality via systematic review.

Methods

A systematic search was performed on Medline and Pubmed to identify relevant studies. Randomized controlled trials, and observational studies assessing SCH or its treatment and the risk of incident cancer or cancer mortality were identified.

Results

A total of 7 cohort and 2 case-control studies met our inclusion criteria. In general, these studies were of medium to good quality. Overall, studies revealed no association between SCH and breast and prostate cancer. On

SUBMITTER: Gomez-Izquierdo J 

PROVIDER: S-EPMC7285584 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature