Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration.

ABSTRACT:

Background

Inflammation-related atherosclerotic peripheral vascular disease is a major end organ complication of diabetes mellitus that results in devastating morbidity and mortality. Extracellular vesicles (EVs) are nano-sized particles that contain molecular cargo and circulate in the blood. Here, we examined EV protein cargo from diabetic individuals and whether these EVs cause functional changes in endothelial cells.

Methods

We quantified inflammatory protein levels in plasma-derived EVs from a longitudinal cohort of euglycemic and diabetic individuals and used in vitro endothelial cell biological assays to assess the functional effects of these EVs with samples from a cross-sectional cohort.

Results

We found several significant associations between EV inflammator

SUBMITTER: Wu SF 

PROVIDER: S-EPMC7285586 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature