PPAI: a web server for predicting protein-aptamer interactions.

ABSTRACT:

Background

The interactions between proteins and aptamers are prevalent in organisms and play an important role in various life activities. Thanks to the rapid accumulation of protein-aptamer interaction data, it is necessary and feasible to construct an accurate and effective computational model to predict aptamers binding to certain interested proteins and protein-aptamer interactions, which is beneficial for understanding mechanisms of protein-aptamer interactions and improving aptamer-based therapies.

Results

In this study, a novel web server named PPAI is developed to predict aptamers and protein-aptamer interactions with key sequence features of proteins/aptamers and a machine learning framework integrated adaboost and random forest. A new method for extracting several

SUBMITTER: Li J 

PROVIDER: S-EPMC7285591 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature