Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study.

ABSTRACT:

Background

Periostin is a matricellular protein and is a useful marker in respiratory diseases. However, the roles of periostin in patients with obstructive sleep apnea (OSA) remain unclear. Several in vitro studies have suggested that mechanical stress, hypoxia, impaired metabolism, and kidney injury, which often accompany OSA, may upregulate the expression of periostin. Meanwhile, serum periostin level has been negatively associated with body mass index (BMI) in the general population. In this study, we hypothesized that a high level of serum periostin despite being overweight/obese may discriminate severe OSA or OSA with comorbidities from mild OSA with obesity alone. We aimed to clarify the roles of periostin in patients with OSA to assist in elucidating the heterogeneity of OS

SUBMITTER: Sunadome H 

PROVIDER: S-EPMC7285606 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature