Survival of infants with spina bifida and the role of maternal prepregnancy body mass index.

ABSTRACT:

Objective

To investigate first-year survival of infants born with spina bifida, and examine the association of maternal prepregnancy body mass index (BMI) with infant mortality.

Methods

This is a retrospective cohort study of 1,533 liveborn infants with nonsyndromic spina bifida with estimated dates of delivery from 1998 to 2011 whose mothers were eligible for the National Birth Defects Prevention Study (NBDPS). NBDPS data were linked to death records to conduct survival analyses. Kaplan-Meier survival functions estimated mortality risk over the first year of life. Cox proportional hazards models estimated hazard ratios (HRs) for maternal prepregnancy BMI categorized as underweight (<18.5), normal (18.5-24.9), overweight (25-29.9), and obese (≥30).

Results

Infant mort

SUBMITTER: Pace ND 

PROVIDER: S-EPMC7285624 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature