Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation.

ABSTRACT:

Background

Comorbidities are common in patients with atrial fibrillation (AF) and affect prognosis, yet are often undertreated. However, contemporary rates of use of guideline-directed therapies (GDT) for non-AF comorbidities and their association with outcomes are not well described.

Methods

We used the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF) to test the association between GDT for non-AF comorbidities and major adverse cardiac or neurovascular events (MACNE; cardiovascular death, myocardial infarction, stroke/thromboembolism, or new-onset heart failure), all-cause mortality, new-onset heart failure, and AF progression. Adjustment was performed using Cox proportional hazards models and logistic regression.

Results

Only 6,782 (33%) of the 20,4

SUBMITTER: Loring Z 

PROVIDER: S-EPMC7285625 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature