Antinociceptive Action of Moringa peregrina is Mediated by an Interaction with α2-Adrenergic Receptor

ABSTRACT: Background:Moringa peregrina (M. peregrina) is an edible, drought-resistant tree that is native to semi-arid countries. It is used as a painkiller in folk medicine. Aims:To study the antinociceptive effects of the leaf extract of M. peregrina in mice. Study Design:Animal experimentation. Methods:We employed thermal (hot plate and tail-immersion tests) and chemical (writhing and formalin tests) pain models in male BALB/c mice (eight animals per group) to investigate the mechanisms involved in the antinociceptive actions of M. peregrina. Additionally, we identified the chemical constituents present in the extract of M. peregrina by using liquid chromatography-mass spectrometry analysis, and predicted the possible active constituents that interact with the receptor based on molecular docking

SUBMITTER: Jaffal SM 

PROVIDER: S-EPMC7285663 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature