Racial differences in CD8⁺ T cell infiltration in breast tumors from Black and White women.

ABSTRACT:

Background

African American/Black women with breast cancer have poorer survival than White women, and this disparity persists even after adjusting for non-biological factors. Differences in tumor immune biology have been reported between Black and White women, and the tumor immune milieu could potentially drive racial differences in breast cancer etiology and outcome.

Methods

We examined the association of CD8⁺ cytotoxic T cells with clinical-pathological variables in the Women's Circle of Health Study (WCHS) population of predominantly Black breast cancer patients. We evaluated 688 invasive breast tumor samples (550 Black, 138 White) using immunohistochemical staining of tissue microarray slides. CD8⁺ T cells were scored for each patient tumor sample w

SUBMITTER: Abdou Y 

PROVIDER: S-EPMC7285742 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature