Collapsing the list of myocardial infarction-related differentially expressed genes into a diagnostic signature.

ABSTRACT:

Background

Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central component of CAD pathogenesis is a chronic vascular inflammation. However, the mechanisms underlying the changes that occur in T, B and NK lymphocytes, monocytes and other immune cells during CAD and MI are still poorly understood. One of those pathogenic mechanisms might be the dysregulation of intracellular signaling pathways in the immune cells.

Methods

In the present study we performed a transcriptome profiling in peripheral blood mononuclear cells of MI patients and controls. The machine learning algorithm was then used to search for MI-associated signatures, th

SUBMITTER: Osmak G 

PROVIDER: S-EPMC7285786 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature