Histology and its prognostic effect on KRAS-mutated colorectal carcinomas in Korea.

ABSTRACT: KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from South Korea. A retrospective review of the results from KRAS mutation testing, as well as evaluation of the histology of 310 cases of CRC at various stages, were performed. Cross-tabulation and survival analysis were performed according to the KRAS status. Patients with KRAS mutation more frequently exhibited serrated and papillary architectures (P=0.009 and P=0.014, respectively). KRAS mutation was an independent unfavorable prognost

SUBMITTER: Lee HS 

PROVIDER: S-EPMC7285809 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature