Clinicopathological and mutational differences between tumors with multiple metastases and single lung metastasis in colorectal cancer.

ABSTRACT: Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study examined tumor heterogeneity by comparing the mutation status between primary colorectal cancer (CRC) and corresponding metastatic lesions to identify prognostic factors associated with single lung metastasis and multiple metastases. The present study enrolled 31 cases of CRC; 20 cases with multiple metastases and 11 cases with single lung metastasis. Clinicopathologically, all cases with multiple metastases were tubular adenocarcinoma, and 3/11 cases with single metastasis were mu

SUBMITTER: Yanai Y 

PROVIDER: S-EPMC7285844 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature