Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations.

ABSTRACT: Genome-wide association studies have revolutionized our understanding of the genetic underpinnings of cardiometabolic disease. Yet, the inadequate representation of individuals of diverse ancestral backgrounds in these studies may undercut their ultimate potential for both public health and precision medicine. The goal of this review is to describe the imperativeness of studying the populations who are most affected by cardiometabolic disease, to the aim of better understanding the genetic underpinnings of the disease. We support this premise by describing the current variation in the global burden of cardiometabolic disease and emphasize the importance of building a globally and ancestrally representative genetics evidence base for the identification of population-specific variants, fine-

SUBMITTER: Fernandez-Rhodes L 

PROVIDER: S-EPMC7285892 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature