Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice.

ABSTRACT: Drug resistant pathogens are on the rise, and new treatments are needed for bacterial infections. Efforts toward antimicrobial discovery typically identify compounds that prevent bacterial growth in microbiological media. However, the microenvironments to which pathogens are exposed during infection differ from rich media and alter the biology of the pathogen. We and others have therefore developed screening platforms that identify compounds that disrupt pathogen growth within cultured mammalian cells. Our platform focuses on Gram-negative bacterial pathogens, which are of particular clinical concern. We screened a panel of 707 drugs to identify those with efficacy against Salmonella enterica Typhimurium growth within macrophages. One of the drugs identified, clofazimine (CFZ), is a

SUBMITTER: Nagy TA 

PROVIDER: S-EPMC7285895 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature