Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

ABSTRACT:

Objectives

To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.

Subject patients/methods

The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.

Results

A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indic

SUBMITTER: Segura A 

PROVIDER: S-EPMC7285905 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature