Integrative transcriptome analysis identified a BMP signaling pathway-regulated lncRNA AC068643.1 in IDH mutant and wild-type glioblastomas.

ABSTRACT: Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutant (IDH ^MT) and wild-type (IDH ^WT) subtypes, and each is associated with distinct tumor behavior and prognosis. The present study aimed to investigate differentially expressed long non-coding (lnc)RNAs and mRNAs between IDH ^MT and IDH ^WT GBMs, as well as to explore the interaction and potential functions of these RNAs. A total of 132 GBM samples with RNA profiling data (10 IDH ^MT and 122 IDH ^WT cases) were obtained from The Cancer Genome Atlas, and 62/78 and 142/219 up/downregulated lncRNAs and mRNAs between IDH ^MT and IDH ^WT GBMs were identified, respectively. Multivariate

SUBMITTER: Huang GH 

PROVIDER: S-EPMC7285920 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature