Comparative characterization of Viperidae snake venoms from Peru reveals two compositional patterns of phospholipase A₂ expression.

ABSTRACT: Snake species within the Bothrops complex (sensu lato) are of medical relevance in Latin America, but knowledge on their venom characteristics is limited, or even unavailable, for some taxa. Perú harbors 17 species of pit vipers, within the genera Bothrops, Bothriechis, Bothrocophias, Porthidium, Crotalus, and Lachesis. This study compared the venoms of twelve species, through chromatographic and electrophoretic profiles, as well as proteolytic and phospholipase A₂ (PLA₂) activities. Also, proteomic profiles were analyzed for nine of the venoms using a shotgun approach. Results unveiled conspicuous differences in the expression of venom PLA₂s among species, six of them presenting scarce levels as judge

SUBMITTER: Lomonte B 

PROVIDER: S-EPMC7285926 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature