Pituitary dysfunction in patients with ANCA associated vasculitis: prevalence, presentation, and outcomes.

ABSTRACT:

Background

The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are rare multisystem autoimmune diseases characterized by inflammatory cell infiltration causing necrosis of small blood vessels. Pituitary involvement in AAV is poorly described. This study aimed to describe the prevalence, clinical characteristics, and outcomes of pituitary involvement in patients with AAV.

Methods

A total of 150 patients diagnosed with AAV and hospitalized in the China-Japan Friendship Hospital between 2009 and 2019 were enrolled in this retrospective study. Patients diagnosed with pituitary involvement in AAV were selected for inclusion.

Results

Three patients (2%) were identified with pituitary involvement. Two patients had positive ANCA titers, one with protein

SUBMITTER: Li C 

PROVIDER: S-EPMC7285954 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature