Biochemical and immunochemical characterization of venoms from snakes of the genus Agkistrodon.

ABSTRACT: In the present work, venoms from five species of the genus Agkistrodon were evaluated in terms of their enzymatic (Phospholipase A₂ and caseinolytic) and biological (edema forming, hemorrhagic, procoagulant and lethal) effects. Horses were used to produce monovalent hyperimmune sera against each of three venoms (A. bilineatus, A. contortrix and A. piscivorus) and their neutralizing potency, expressed as Median Effective Dose (ED₅₀), was determined against the venoms of all five species. In terms of PLA₂ and caseinolytic activities, all venoms are extremely homogeneous. PLA₂ activity is high, while caseinolytic activity is low when in contrast with that of the rattlesnake Crotalus simus. On the other hand, biological ac

SUBMITTER: Roman-Dominguez L 

PROVIDER: S-EPMC7285990 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature