Systems Genetics for Mechanistic Discovery in Heart Diseases.

ABSTRACT: Cardiovascular diseases are the leading cause of death worldwide. Complex diseases with highly heterogenous disease progression among patient populations, cardiovascular diseases feature multifactorial contributions from both genetic and environmental stressors. Despite significant effort utilizing multiple approaches from molecular biology to genome-wide association studies, the genetic landscape of cardiovascular diseases, particularly for the nonfamilial forms of heart failure, is still poorly understood. In the past decade, systems-level approaches based on omics technologies have become an important approach for the study of complex traits in large populations. These advances create opportunities to integrate genetic variation with other biological layers to identify and prioritize ca

SUBMITTER: Rau CD 

PROVIDER: S-EPMC7286104 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature