Trends in Off-Label Drug Use in Ambulatory Settings: 2006-2015.

ABSTRACT: Off-label drug use in children is common and potentially harmful. In most previous off-label use research, authors studied hospitalized children, specific drug classes, or non-US settings. We characterized frequencies, trends, and reasons for off-label systemic drug orders for children in ambulatory US settings. Using nationally representative surveys of office-based physicians (National Ambulatory Medical Care Surveys, 2006-2015), we studied off-label orders of systemic drugs for children age <18 based on US Food and Drug Administration-approved labeling for age, weight, and indication. We characterized the top classes and diagnoses with off-label orders and analyzed factors and trends of off-label orders using logistic regression. Physicians ordered ≥1 off-label systemic drug at 18.5% (9

SUBMITTER: Hoon D 

PROVIDER: S-EPMC7286122 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature