Hypoxia Modulates Platelet Purinergic Signalling Pathways.

ABSTRACT:

Background

 Hypoxia resulting from ascent to high-altitude or pathological states at sea level is known to increase platelet reactivity. Previous work from our group has suggested that this may be adenosine diphosphate (ADP)-specific. Given the clinical importance of drugs targeting ADP pathways, research into the impact of hypoxia on platelet ADP pathways is highly important.

Methods

 Optimul aggregometry was performed on plasma from 29 lowland residents ascending to 4,700 m, allowing systematic assessment of platelet reactivity in response to several platelet agonists. Aggregometry was also performed in response to ADP in the presence of inhibitors of the two main ADP receptors, P2Y₁ and P2Y₁₂ (MRS2500 and cangrelor, respectively). Phosphorylation of

SUBMITTER: Paterson GG 

PROVIDER: S-EPMC7286126 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature