Ontology highlight
ABSTRACT:
SUBMITTER: Yu W
PROVIDER: S-EPMC7286298 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yu Wenjie W Sun Zhao Z Sweat Yan Y Sweat Mason M Venugopalan Shankar Rengasamy SR Eliason Steven S Cao Huojun H Paine Michael L ML Amendt Brad A BA
Development (Cambridge, England) 20200604 11
Epithelial signaling centers control epithelial invagination and organ development, but how these centers are specified remains unclear. We report that <i>Pitx2</i> (the first transcriptional marker for tooth development) controls the embryonic formation and patterning of epithelial signaling centers during incisor development. We demonstrate using <i>Krt14<sup>Cre</sup></i> /<i>Pitx2<sup>flox/flox</sup></i> (<i>Pitx2<sup>cKO</sup></i> ) and <i>Rosa26<sup>CreERT</sup>/Pitx2<sup>flox/flox</sup></ ...[more]