Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers.

ABSTRACT: Epithelial signaling centers control epithelial invagination and organ development, but how these centers are specified remains unclear. We report that Pitx2 (the first transcriptional marker for tooth development) controls the embryonic formation and patterning of epithelial signaling centers during incisor development. We demonstrate using Krt14^Cre /Pitx2^flox/flox (Pitx2^cKO ) and Rosa26^CreERT/Pitx2^flox/flox mice that loss of Pitx2 delays epithelial invagination, and decreases progenitor cell proliferation and dental epithelium cell differentiation. Developmentally, Pitx2 regulates formation of the Sox2⁺ labial cervical loop (LaCL) stem cell niche in concert with two signalin

SUBMITTER: Yu W 

PROVIDER: S-EPMC7286298 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature