Dataset Information

Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study.

ABSTRACT:

Introduction

The aim of the study was to identify predictors of surgical complications of transurethral resection of bladder tumour (TURBT).

Material and methods

We prospectively recruited 983 consecutive patients undergoing TURBT within 7 months in six academic institutions. All patients were followed up from the surgery up to 30 days postoperatively with at least one telephone contact at the end of the observation. The primary study endpoint was any intra- or postoperative surgical complication. For the identification of predictors of complications, univariate and multivariate logistic regression models were used. Trial registration: ClinicalTrials.gov (NCT03029663). Registered 24 January 2017.

Results

Surgical complications were noticed in 228 (23.2%) patients, including 83 (8.4%) patients with more than one complication and 33 cases of Clavien-Dindo grade 3 complications (3.3%). The most common in-hospital complications were bleeding (n = 139, 14.1%) and bladder perforation (n = 46, 4.7%). In a multivariate analysis, nicotine use, high ASA score, and the presence of high-grade tumour were the most significant predictors of high-grade complications. The stage of the disease was the strongest predictor of bleeding, while the presence of muscle in the specimen and resident surgeon were the strongest predictors for bladder perforation.

Conclusions

TURBT poses a significant risk of surgical complications, the majority of which are of low grade.

SUBMITTER: Poletajew S

PROVIDER: S-EPMC7286316 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study.

Poletajew Sławomir S Krajewski Wojciech W Gajewska Dominika D Sondka-Migdalska Joanna J Borowik Michał M Buraczyński Paweł P Dzięgała Mateusz M Łykowski Marcin M Przudzik Maciej M Tukiendorf Andrzej A Woźniak Rafał R Bar Krzysztof K Jabłonowski Zbigniew Z Roslan Marek M Słojewski Marcin M Zdrojowy Romuald R Radziszewski Piotr P Dziobek Konrad K

Archives of medical science : AMS 20191007 4

<h4>Introduction</h4>The aim of the study was to identify predictors of surgical complications of transurethral resection of bladder tumour (TURBT).<h4>Material and methods</h4>We prospectively recruited 983 consecutive patients undergoing TURBT within 7 months in six academic institutions. All patients were followed up from the surgery up to 30 days postoperatively with at least one telephone contact at the end of the observation. The primary study endpoint was any intra- or postoperative surgi ...[more]

PMID: 32542089

Similar Datasets

Project description:BackgroundRepeat transurethral resection of bladder tumour (reTURB) is a conventional treatment for non-muscle-invasive bladder cancer (NMIBC) to enhance prognosis. However, the necessity of reTURB in NMIBC remains controversial owing to upstaging of treatments and new evidence.ObjectivesWe performed an umbrella review to determine the need for reTURB in patients with NMIBC.DesignWe extracted data from meta-analyses that were screened out after a systematic search of PubMed, Embase, the Web of Science and the Cochrane Database of Systematic Reviews.MethodsRisk of Bias in Systematic Reviews and the Grading of Recommendations, Assessment, Development and Evaluation tools were used to assess the quality of each included meta-analysis and outcomes.ResultsOur study included seven meta-analyses. Two studies assessed the efficiency of reTURB in patients who underwent en bloc resection of bladder tumours (ERBT). Patients who underwent ERBT reported low residual tumour and upstaging rates of 5.9% and 0.3%, respectively. Conversely, patients who underwent conventional transurethral resection for bladder cancer (cTURB) had high residual tumour rates. Patients who underwent cTURB and reTURB had significantly improved 1-year recurrence-free survival (RFS) compared to those who underwent initial cTURB alone. In terms of progression-free survival (PFS), a meta-analysis reported that patients who underwent cTURB and reTURB had significantly improved PFS compared with those who underwent initial cTURB alone. In the subgroup analyses of ERBT, reTURB did not affect the RFS and PFS of patients who received ERBT. Currently, only a limited number of randomised clinical trials have evaluated reTURB, and various factors have influenced its efficacy.ConclusionThere was significant variation in survival outcomes among patients undergoing reTURB. The necessity and efficacy of reTURB depend on numerous factors, such as surgical approach, equipment and medication usage. Patients eligible for ERBT may constitute a group that does not require reTURB. Further clinical trials are required to validate these findings.RegistrationThis umbrella review was registered with the International Prospective Register of Systematic Reviews (CRD42023439078).

Dataset Information

Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study.

Introduction

Material and methods

Results

Conclusions

Publications

Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets