Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus-Related Oropharyngeal Carcinoma.

ABSTRACT:

Importance

Human papillomavirus-related oropharyngeal carcinoma (HPV-OPC) is increasing in incidence in the United States. Although HPV-OPC has favorable prognosis, 10% to 25% of HPV-OPCs recur. Detection of human papillomavirus (HPV) DNA in oral rinses is associated with HPV-OPC, but its potential as a prognostic biomarker is unclear.

Objective

To determine whether HPV DNA detection in oral rinses after treatment for HPV-OPC is associated with recurrence and survival.

Design, setting, and participants

Prospective cohort study of patients with incident HPV-OPC diagnosed from 2009 to 2013 at 4 academic tertiary referral cancer centers in the United States. Oral rinse samples were collected at diagnosis and after treatment (9, 12, 18, and 24 months after diagnosis), and

SUBMITTER: Rettig EM 

PROVIDER: S-EPMC7286348 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature