Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma.

ABSTRACT:

Background

The association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown.

Objective

To identify prognostic lncRNAs involved in the spontaneous regression of NB.

Methods

Differential expression analyses were performed between those samples with an outcome of death in stage 4 NB group and those samples with an outcome of survival in stage 4S NB group in two independent public datasets, respectively. Univariate Cox proportional hazard regression survival analysis was performed in each of the entire cohort to identify those lncRNAs significantly associated with overall survival (OS). Those lncRNAs independently associated with OS were then identified by multivariate Cox survival anal

SUBMITTER: Meng X 

PROVIDER: S-EPMC7286466 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature