Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy.

ABSTRACT:

Objectives

To examine interocular asymmetry of foveal avascular zone (FAZ) and parafoveal capillary density metrics in sickle cell retinopathy (SCR) using optical coherence tomography angiography (OCT-A).

Methods

This cross-sectional, retrospective study evaluated SCR patients and unaffected controls who underwent 3x3mm macular OCT-A imaging using a spectral domain-OCT system. FAZ (area, perimeter, and acircularity index) and parafoveal capillary density metrics were computed for both eyes of each participant. In unaffected controls, interocular difference in FAZ and parafoveal capillary density metrics were evaluated using Bland-Altman plots. SCR patients with interocular difference outside the upper 97.5% and lower 2.5% limits of agreement from controls were defined as hav

SUBMITTER: Zhou DB 

PROVIDER: S-EPMC7286490 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature