Differences in the molecular profile of endometrial cancers from British White and British South Asian women.

ABSTRACT:

Objectives

To identify differences in the mutational profile of endometrial tumours between British White (BW) and South Asian (BSA) women.

Methods

We analysed primary tumours from matched cohorts of British White (BW) and British South Asian (BSA) women resident in Leicestershire diagnosed with EC. Next Generation Sequencing was performed to investigate mutational differences in a panel of 10 genes previously identified as being commonly mutated in EC. The presence of somatic Mismatch Repair (MMR) gene deficiencies was determined by immunohistochemistry.

Results

In total, 57 tumours (27 BSA and 30 BW) were sequenced. There was no significant difference in the overall mutation frequency of the 10 genes analysed; however, numerous differences were observed between the

SUBMITTER: Polymeros K 

PROVIDER: S-EPMC7286498 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature