Real-time detection of single-molecule reaction by plasmon-enhanced spectroscopy.

ABSTRACT: Determining structural transformations of single molecules (SMs) is an important fundamental scientific endeavor. Optical spectroscopies are the dominant tools used to unravel the physical and chemical features of individual molecules and have substantially contributed to surface science and biotechnology. In particular, Raman spectroscopy can identify reaction intermediates and reveal underlying reaction mechanisms; however, SM Raman experiments are subject to intrinsically weak signal intensities and considerable signal attenuation within the spectral dispersion systems of the spectrometer. Here, to monitor the structural transformation of an SM on the millisecond time scale, a plasmonic nanocavity substrate has been used to enable Raman vibrational and fluorescence spectral signals to b

SUBMITTER: Li CY 

PROVIDER: S-EPMC7286666 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature