Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound.

ABSTRACT: The detection of different frequencies in sound is accomplished with remarkable precision by the basilar membrane (BM), an elastic, ribbon-like structure with graded stiffness along the cochlear spiral. Sound stimulates a wave of displacement along the BM with maximal magnitude at precise, frequency-specific locations to excite neural signals that carry frequency information to the brain. Perceptual frequency discrimination requires fine resolution of this frequency map, but little is known of the intrinsic molecular features that demarcate the place of response on the BM. To investigate the role of BM microarchitecture in frequency discrimination, we deleted extracellular matrix protein emilin 2, which disturbed the filamentous organization in the BM. Emilin2 ^-/- mice di

SUBMITTER: Russell IJ 

PROVIDER: S-EPMC7286672 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature